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The subgingival microbiota of Papillon-Lefèvre syndrome.
[papillon-lefèvre syndrome]
There
is
little
information
about
the
microbiologic
profiles
of
periodontal
lesions
in
Papillon-
Lefèvre
syndrome
(
PLS
)
and
the
significance
of
bacteria
in
the
pathogenesis
of
periodontitis
in
these
patients
.
This
comprehensive
analysis
of
the
subgingival
microbiota
in
patients
with
PLS
used
16
S
ribosomal
RNA
(
rRNA
)
clonal
analysis
and
the
16
S
rRNA-based
Human
Oral
Microbe
Identification
Microarray
(
HOMIM
)
.
Thirteen
patients
with
PLS
from
seven
unrelated
families
volunteered
for
this
microbiologic
study
.
Subgingival
plaque
was
collected
with
sterile
paper
points
from
multiple
sites
with
≥
5
mm
probing
depth
,
and
whole
genomic
DNA
was
extracted
.
The
16
S
rRNA
genes
were
amplified
,
cloned
,
and
sequenced
.
The
samples
were
then
probed
for
≈
300
predominant
oral
bacterial
species
using
the
HOMIM
.
T
he
most
commonly
detected
phylotypes
in
the
clonal
analysis
were
Gemella
morbillorum
,
Gemella
haemolysans
,
Granulicatella
adiacens
,
Lachnospiraceae
OT
100
(
EI
074
)
,
Parvimonas
micra
,
Selenomonas
noxia
,
and
Veillonella
parvula
.
As
a
group
,
streptococci
were
commonly
detected
in
these
individuals
.
In
the
HOMIM
analysis
,
a
total
of
170
bacterial
species
/
phylotypes
were
detected
,
with
a
range
of
40
to
80
species
per
patient
with
PLS
.
Of
these
,
12
bacterial
species
were
detected
in
medium
to
high
levels
in
≥
50
%
of
the
individuals
.
The
high
-frequency
strains
were
clustered
into
eight
groups
:
Aggregatibacter
actinomycetemcomitans
,
Campylobacter
spp
.
,
Capnocytophaga
granulosa
,
G
.
morbillorum
,
P
.
micra
,
Porphyromonas
endodontalis
,
Streptococcus
spp
.
,
and
Tannerella
forsythia
.
The
subgingival
microbiota
in
PLS
is
diverse
.
Periodontal
pathogens
commonly
associated
with
chronic
and
aggressive
periodontitis
and
opportunistic
pathogens
may
be
associated
with
the
development
of
severe
periodontitis
in
patients
with
PLS
.
Diseases
Validation
Diseases presenting
"commonly detected phylotypes in the clonal analysis"
symptom
papillon-lefèvre syndrome
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