Rare Diseases Symptoms Automatic Extraction

Oral manifestion of Langerhans cell histiocytosis mimicking inflammation.

[papillon-lefèvre syndrome]

Langerhans cell histiocytosis (LCH) is a rare idiopathic disease characterized by the clonal proliferation of Langerhans cells. LCH affects five children per million population. The peak incidence is from 1 to 4 years of age. LCH involves the head and neck region quite commonly. Oral soft tissue lesions are also common. The differential diagnosis of oral LCH includes leukemia, neutropenia, prepubertal periodontitis, hypophosphatasia, fibrous dysplasia, and Papillon-Lefevre syndrome. The prognosis of LCH depends on early detection and appropriate management. Surgical management alone is used in 50% of cases with an additional 23% of the lesions being treated with both surgery and radiation therapy. A case of LCH in a 6-year-old girl involving the mid root level of developing first permanent molar with a floating developing tooth bud of permanent second molar mimicking an inflammation is reported.

Diseases presenting "early detection" symptom

  • 22q11.2 deletion syndrome
  • acute rheumatic fever
  • adrenomyeloneuropathy
  • allergic bronchopulmonary aspergillosis
  • carcinoma of the gallbladder
  • child syndrome
  • cholangiocarcinoma
  • classical phenylketonuria
  • congenital diaphragmatic hernia
  • cowden syndrome
  • cystinuria
  • erythropoietic protoporphyria
  • esophageal adenocarcinoma
  • esophageal squamous cell carcinoma
  • fabry disease
  • homocystinuria without methylmalonic aciduria
  • inclusion body myositis
  • kallmann syndrome
  • krabbe disease
  • oral submucous fibrosis
  • papillon-lefèvre syndrome
  • phenylketonuria
  • pyomyositis
  • von hippel-lindau disease

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