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Estimation of the Serum and the Salivary Trace Elements in OSMF Patients.
[oral submucous fibrosis]
Gutkha
packets
contain
trace
elements
like
copper
,
zinc
,
iron
and
magnesium
.
This
study
compared
the
levels
of
the
trace
elements
in
patients
with
gutkha
eating
habits
with
or
without
oral
submucous
fibrosis
and
in
healthy
patients
.
A
total
of
75
patients
were
included
in
this
study
and
they
were
divided
into
three
groups
;
the
individuals
with
a
history
of
gutkha
intake
with
OSMF
,
the
individuals
with
a
history
of
gutkha
intake
without
OSMF
and
apparently
healthy
individuals
without
OSMF
and
without
any
habits
.
Blood
and
saliva
was
collected
and
they
were
subjected
for
analysis
by
using
atomic
absorption
spectrometry
and
a
differential
pulse
anodic
stripping
voltmeter
.
The
results
were
tabulated
and
they
were
subjected
to
a
statistical
analysis
.
There
was
a
significant
difference
in
the
serum
Mg
and
Fe
levels
between
the
patients
with
habits
and
the
normal
healthy
individuals
.
A
significant
difference
was
observed
in
the
serum
zinc
levels
in
the
patients
with
habits
with
and
without
OSMF
.
Altered
serum
trace
element
levels
are
documented
in
malignant
cases
and
they
are
considered
to
be
good
biomarkers
for
malignancies
.
The
serum
copper
and
Zn
levels
and
the
Cu
/
Zn
ratio
in
OSMF
patients
can
be
considered
as
the
markers
which
show
a
susceptibility
towards
cancer
.
Diseases
Validation
Diseases presenting
"they are considered to be good biomarkers for malignancies"
symptom
oral submucous fibrosis
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