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A random Abstract
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Inflammation in the context of oral cancer.
[oral submucous fibrosis]
The
link
between
cancer
and
inflammation
is
specific
transcription
factors
that
once
activated
have
the
capacity
to
enhance
expression
of
genes
that
are
common
to
both
the
regulation
and
the
production
of
mediators
of
inflammation
,
and
also
to
the
regulation
of
the
survival
and
proliferation
of
cancer
cells
.
Cellular
pathways
activated
by
chronic
inflammation
brought
about
by
chronic
infections
,
by
immune-mediated
diseases
,
or
by
dysregulated
wound
healing
at
sites
of
repetitive
tissue
injury
,
constitute
risk
factors
for
initial
cell
transformation
and
for
cancer
progression
.
In
established
cancers
,
the
cancer
cells
induce
development
of
an
exaggerated
inflammatory
state
in
the
stroma
,
which
in
turn
promotes
cancer
growth
,
invasion
and
metastasis
.
Inflammatory
cells
of
myeloid
origin
in
the
tumour-associated
stroma
,
mediate
suppression
of
immune
responses
against
cancer
cells
,
which
suppression
favours
tumour
growth
.
Oral
submucous
fibrosis
,
and
to
a
lesser
extent
oral
lichen
planus
are
precancerous
conditions
in
which
immuno-
inflammatory
processes
are
implicated
in
their
pathogenesis
,
and
in
their
cancerous
transformation
,
if
it
occurs
.
Although
there
is
some
evidence
for
an
association
between
oral
squamous
cell
carcinoma
on
the
one
hand
and
dento-
gingival
bacterial
plaques
and
chronic
periodontitis
on
the
other
hand
,
the
role
of
inflammation
as
the
sole
cause
of
cancerous
transformation
in
such
cases
is
not
proven
.
The
purpose
of
this
article
is
to
elaborate
on
some
of
the
more
important
relationships
between
oral
cancer
and
inflammation
,
and
to
comment
on
the
role
of
inflammation
in
the
pathogenesis
of
oral
squamous
cell
carcinoma
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
