Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Pathogenesis and therapeutic intervention of oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSF
)
is
a
chronic
,
progressive
,
potentially
malignant
condition
affecting
the
oral
cavity
and
frequently
involving
the
upper
part
of
the
aerodigestive
tract
including
the
oropharynx
and
the
upper
part
of
the
esophagus
.
It
is
characterized
by
juxtaepithelial
inflammatory
reaction
and
progressive
fibrosis
of
lamina
propria
,
leading
to
stiffening
of
the
oral
mucosa
eventually
causing
trismus
.
This
condition
is
associated
with
significant
morbidity
and
high
risk
of
malignancy
.
Over
the
years
,
several
drugs
and
combinations
have
been
tried
for
the
treatment
of
submucous
fibrosis
,
but
with
limited
success
,
because
of
its
unclear
molecular
pathogenesis
.
Till
date
,
there
are
no
known
effective
treatments
for
OSF
.
The
aim
of
this
article
is
to
emphasize
on
the
molecular
changes
taking
place
in
OSF
and
possible
therapeutic
interventions
.
