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Oral submucous fibrosis--a potentially malignant condition of growing concern.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSF
)
is
a
premalignant
condition
that
primarily
affects
the
oral
cavity
.
The
clinical
hallmark
of
this
disease
is
the
development
of
progressive
trismus
.
The
latter
is
a
direct
consequence
of
loss
of
the
normal
fibro-elasticity
of
the
oral
mucosa
and
replacement
of
the
fibromuscular
connective
tissue
by
the
deposition
of
dense
collagen
.
This
change
in
the
oral
mucosa
is
aetiologically
linked
to
the
areca
nut
chewing
habit
where
the
development
of
OSF
results
from
the
interaction
of
the
mucosa
with
the
chemical
constituents
of
areca
.
Areca
nuts
are
used
as
a
masticatory
substance
either
alone
,
in
a
self-prepared
quid
or
in
various
commercial
preparations
known
as
paan
masala
and
gutka
.
The
habitual
usage
of
these
products
is
rapidly
increasing
and
oral
health
professionals
globally
are
likely
to
encounter
patients
with
this
disease
.
The
potentially
malignant
nature
of
OSF
is
well
documented
and
habitual
areca
nut
chewing
even
in
the
absence
of
tobacco
is
an
independent
risk
factor
for
oral
cancer
.
Public
health
education
against
the
areca
nut
chewing
habit
is
essential
to
eradicate
the
deleterious
effects
of
this
habit
on
oral
health
.
