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Molecular and phenotypic expression of decorin as modulator of angiogenesis in human potentially malignant oral lesions and oral squamous cell carcinomas.
[oral submucous fibrosis]
Decorin
is
an
extracellular
matrix
,
multifunctional
small
proteoglycan
molecule
in
tumor
stroma
that
has
been
shown
to
be
modulator
of
angiogenesis
.
No
clinical
data
is
available
so
far
on
decorin
expression
and
survival
outcome
of
oral
cancer
.
The
aim
of
the
present
study
was
to
examine
molecular
and
phenotypic
expression
of
two
angiogenesis
modulators
viz
.
decorin
and
vascular
endothelial
growth
factor
-
A
(
VEGF-A
)
in
human
potentially
malignant
oral
lesions
(
PMOLs
)
and
oral
squamous
cell
carcinomas
(
OSCC
)
in
relation
to
clinico-pathological
variables
and
survival
outcome
.
Tissue
biopsies
were
obtained
from
72
PMOLs
,
108
OSCC
and
52
healthy
controls
.
The
PMOLs
included
cases
of
leukoplakias
and
oral
submucous
fibrosis
.
Immunohistochemistry
was
performed
using
antibodies
against
decorin
,
VEGF-A
and
CD-
31
.
Messenger-ribonucleic
acid
(
mRNA
)
expression
was
analyzed
by
using
real-time
polymerase
chain
reaction
.
Cytoplasmic
staining
of
decorin
was
observed
in
the
basal
layer
of
epithelium
in
53
(
73
.
61
%
)
cases
of
PMOLs
and
in
peritumoral
stroma
in
55
(
50
.
92
%
)
cases
of
OSCC
.
None
of
the
cases
showed
nuclear
expression
of
decorin
.
Decorin
expression
both
at
phenotypic
and
molecular
level
was
found
to
be
down-regulated
from
PMOLs
to
OSCC
.
Lymph
node
metastasis
and
reduced
decorin
expression
independently
correlated
with
overall
survival
in
OSCC
.
VEGF-A
expression
had
no
significant
impact
on
survival
outcome
.
Micro
vessel
density
and
VEGF-A
expression
were
significantly
associated
with
reduced
decorin
expression
in
tumor
stroma
suggesting
,
decorin
as
angiogenic
modulator
in
OSCC
.
Down-regulation
of
decorin
expression
and
the
presence
of
lymph
node
metastasis
were
adverse
factor
independently
affecting
overall
survival
in
OSCC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated