Biochemical markers in oral submucous fibrosis: A review and update.

[oral submucous fibrosis]

Oral submucous fibrosis (OSMF ) is a potentially malignant oral condition effectively linked to the causative habit of chewing areca nut . Since its first description in the 1950 s , numerous epidemiological , biochemical , histological , and genetic studies have been reported . While most studies point out to the cause and effect of areca nut , co -additive factors are also implicated in the progression and malignant transformation of this condition . Biochemical investigations have concentrated on outlining such changes in the blood , serum or tissues of these patients and have given insights on the possible pathogenesis of OSMF . This article attempts to compile details of biochemical investigations in OSMF and summarize and infer on the findings .