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Spirulina and pentoxyfilline - a novel approach for treatment of oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
is
a
habit
associated
insidious
precancerous
condition
of
the
oral
cavity
commonly
found
in
Asian
countries
.
Many
treatment
modalities
have
been
attempted
in
treating
the
condition
apart
from
steroids
which
have
been
the
main
stay
.
Hence
the
present
study
was
designed
to
assess
the
efficacy
of
spirulina
and
pentoxyfilline
and
also
to
compare
them
in
oral
submucous
fibrosis
.
Fourty
Patients
with
clinico-histological
diagnosis
of
oral
sub
mucous
fibrosis
were
selected
and
divided
into
two
groups
with
20
in
each
group
by
simple
randomization
method
.
Group
I
received
Pentoxyfilline
and
Group
II
Spirulina
for
period
of
3
months
.
The
efficacy
was
assessed
by
parameters
like
mouth
opening
,
burning
sensation
and
tongue
protrusion
using
vernier
caliper
,
visual
analog
scale
and
a
metric
scale
respectively
along
with
the
side
effects
.
Student
's
t-test
was
applied
to
obtain
the
results
.
Both
Pentoxyfilline
and
Spirulina
groups
showed
statistically
significant
results
(
p
=
0
.
000
)
in
all
the
three
parameters
namely
mouth
opening
,
burning
sensation
and
tongue
protrusion
.
On
comparing
both
the
drugs
statistically
insignificant
results
were
obtained
for
mouth
opening
(
p
=
0
.
35
)
and
tongue
protrusion
(
p
=
0
.
25
)
but
statistically
significant
difference
was
seen
in
subjective
parameter
i
.
e
burning
sensation
(
p
=
0
.
04
)
.
Side
effects
like
bloating
of
stomach
,
nausea
and
gastritis
were
noted
in
the
pentoxyfilline
group
in
contrast
to
Spirulina
group
.
Newer
drugs
Pentoxyfilline
and
Spirulina
showed
promising
results
in
treatment
of
Oral
sub
mucous
fibrosis
.
Spirulina
was
used
for
the
first
time
for
treatment
of
Oral
submucous
fibrosis
(
OSMF
)
and
it
proved
to
be
superior
than
pentoxyfilline
as
no
side
effects
were
observed
.
Also
it
was
superior
in
reducing
burning
sensation
and
hence
can
be
advised
in
OSMF
patients
suffering
from
severe
subjective
symptoms
.
Diseases
Validation
Diseases presenting
"first time"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alpha-thalassemia
aniridia
aromatase deficiency
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
congenital adrenal hyperplasia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
heparin-induced thrombocytopenia
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
trochlear dysplasia
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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