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Spirulina and pentoxyfilline - a novel approach for treatment of oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
is
a
habit
associated
insidious
precancerous
condition
of
the
oral
cavity
commonly
found
in
Asian
countries
.
Many
treatment
modalities
have
been
attempted
in
treating
the
condition
apart
from
steroids
which
have
been
the
main
stay
.
Hence
the
present
study
was
designed
to
assess
the
efficacy
of
spirulina
and
pentoxyfilline
and
also
to
compare
them
in
oral
submucous
fibrosis
.
Fourty
Patients
with
clinico-histological
diagnosis
of
oral
sub
mucous
fibrosis
were
selected
and
divided
into
two
groups
with
20
in
each
group
by
simple
randomization
method
.
Group
I
received
Pentoxyfilline
and
Group
II
Spirulina
for
period
of
3
months
.
The
efficacy
was
assessed
by
parameters
like
mouth
opening
,
burning
sensation
and
tongue
protrusion
using
vernier
caliper
,
visual
analog
scale
and
a
metric
scale
respectively
along
with
the
side
effects
.
Student
's
t-test
was
applied
to
obtain
the
results
.
Both
Pentoxyfilline
and
Spirulina
groups
showed
statistically
significant
results
(
p
=
0
.
000
)
in
all
the
three
parameters
namely
mouth
opening
,
burning
sensation
and
tongue
protrusion
.
On
comparing
both
the
drugs
statistically
insignificant
results
were
obtained
for
mouth
opening
(
p
=
0
.
35
)
and
tongue
protrusion
(
p
=
0
.
25
)
but
statistically
significant
difference
was
seen
in
subjective
parameter
i
.
e
burning
sensation
(
p
=
0
.
04
)
.
Side
effects
like
bloating
of
stomach
,
nausea
and
gastritis
were
noted
in
the
pentoxyfilline
group
in
contrast
to
Spirulina
group
.
Newer
drugs
Pentoxyfilline
and
Spirulina
showed
promising
results
in
treatment
of
Oral
sub
mucous
fibrosis
.
Spirulina
was
used
for
the
first
time
for
treatment
of
Oral
submucous
fibrosis
(
OSMF
)
and
it
proved
to
be
superior
than
pentoxyfilline
as
no
side
effects
were
observed
.
Also
it
was
superior
in
reducing
burning
sensation
and
hence
can
be
advised
in
OSMF
patients
suffering
from
severe
subjective
symptoms
.
Diseases
Validation
Diseases presenting
"simple randomization method"
symptom
oral submucous fibrosis
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