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Plasma fibrinogen degradation products in betel nut chewers - with and without oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
has
a
multifactorial
etiology
.
Recent
studies
have
shown
that
there
is
an
increased
level
of
fibrinogen
degradation
products
(
FDP
)
in
plasma
of
OSMF
patients
suggesting
its
possible
role
in
etiopathogenesis
of
OSMF
.
To
detect
the
presence
of
FDP
in
the
plasma
of
betel
nut
chewers
with
and
without
OSMF
and
in
normal
subjects
without
any
habits
,
to
correlate
these
levels
with
respect
to
the
clinical
and
histological
grading
of
OSMF
and
whether
it
can
be
used
as
a
nonsurgical
diagnostic
aid
in
detection
of
suspected
OSMF
cases
.
Study
comprised
of
35
cases
of
betel
nut
chewers
with
OSMF
,
10
patients
with
betel
nut
chewing
habit
but
having
apparently
normal
oral
mucosa
,
and
10
normal
patients
without
any
habits
.
The
patients
were
evaluated
for
plasma
FDP
levels
.
All
the
betel
nut
chewers
with
OSMF
showed
the
presence
of
plasma
FDP
.
However
,
controls
and
subjects
with
habit
,
but
without
OSMF
did
not
show
FDP
in
the
plasma
.
Spearman
's
rank
correlation
was
used
to
find
the
association
between
the
clinical
and
histological
grades
and
it
was
not
statistically
significant
(
P
=
0
.
910
)
and
the
correlation
being
0
.
020
.
Since
only
those
patients
with
OSMF
have
showed
the
presence
of
FDP
in
plasma
,
we
suggest
that
our
test
can
be
utilized
as
a
nonsurgical
diagnostic
aid
in
suspected
OSMF
patients
.