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Arecoline inhibits epithelial cell viability by upregulating the apoptosis pathway: implication for oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSF
)
is
a
chronic
inflammatory
disease
characterized
by
the
accumulation
of
excess
collagen
,
and
areca
nut
chewing
has
been
proposed
as
a
significant
etiological
factor
for
disease
manifestation
.
However
,
the
underlying
molecular
mechanisms
regarding
areca
nut
chewing-induced
OSF
are
only
partially
understood
.
Herein
,
we
reported
that
arecoline
markedly
induced
morphologic
change
in
HaCaT
epithelial
cells
,
but
had
no
obvious
effect
on
Hel
fibroblast
cells
.
MTS
assay
revealed
that
arecoline
significantly
suppressed
HaCaT
cell
viability
.
Moreover
,
flow
cytometric
analysis
indicated
that
arecoline
substantially
promoted
HaCaT
cell
,
but
not
Hel
cell
apoptosis
in
a
dose-dependent
manner
.
Furthermore
,
arecoline-induced
HaCaT
cell
apoptosis
was
found
to
be
associated
with
increased
expression
and
activation
of
cleaved-
Bid
,
cleaved-
PARA
and
cleaved-caspase-
3
.
Collectively
,
our
results
suggest
that
HaCaT
epithelial
cells
are
more
sensitive
than
Hel
fibroblast
cells
to
arecoline-induced
cytotoxicity
,
which
may
be
involved
in
the
pathogenesis
of
OSF
.
Diseases
Validation
Diseases presenting
"but not hel cell apoptosis in a dose-dependent manner"
symptom
oral submucous fibrosis
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