Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Histochemical analysis of polarizing colors of collagen using Picrosirius Red staining in oral submucous fibrosis.
[oral submucous fibrosis]
Oral
Submucous
fibrosis
(
OSMF
)
is
a
common
potentially
malignant
disease
,
which
is
characterized
by
generalized
fibrosis
of
the
oral
soft
tissues
.
It
is
due
to
disproportion
in
the
collagen
deposition
and
degradation
.
The
excess
deposition
of
collagen
results
in
juxta
epithelial
fibro
elastic
changes
and
epithelial
atrophy
.
Neoplastic
changes
in
the
epithelium
usually
precede
the
changes
in
the
connective
tissue
.
The
purpose
of
the
study
was
to
evaluate
the
changes
in
birefringence
of
collagen
using
picrosirius
stain
and
compare
with
haematoxylin
and
eosin
stained
section
.
The
study
was
conducted
on
50
subjects
,
which
included
45
patients
diagnosed
with
different
functional
and
histopathological
grades
of
OSMF
and
5
in
control
group
.
Picrosirius
red
stain
was
used
to
analyze
collagen
both
histopathologically
and
qualitatively
using
polarizing
microscopy
.
Chi
-square
test
at
p
value
<
0
.
05
was
used
to
analyze
the
results
and
the
significance
was
tabulated
.
Collagen
fibers
showed
mixed
birefringence
with
a
shift
in
polarizing
colour
from
yellow
to
red
-orange
in
lamina
propria
,
around
the
muscle
and
blood
vessels
,
which
was
correlating
with
the
conventional
H
&
E
stain
.
The
results
of
present
study
show
a
significant
change
in
birefringence
of
collagen
between
the
various
components
of
connective
tissue
.
This
change
in
birefringence
colors
and
arrangement
of
collagen
fibers
might
give
an
assumption
of
impending
neoplastic
change
in
OSMF
.
How
to
cite
the
article
:
Velidandla
S
,
Gaikwad
P
,
Ealla
KK
,
Bhorgonde
KD
,
Hunsingi
P
,
Kumar
A
.
Histochemical
analysis
of
polarizing
colors
of
collagen
using
Picrosirius
Red
staining
in
oral
submucous
fibrosis
.
J
Int
Oral
Health
2014
;
6
(
1
)
:
33
-
8
.
Diseases
Validation
Diseases presenting
"which is characterized by generalized fibrosis of the oral soft tissues"
symptom
oral submucous fibrosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom