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Estimation of serum β2-microglobulin in potentially malignant disorders and squamous cell carcinoma of the oral cavity: A clinicopathological study.
[oral submucous fibrosis]
Tumor
markers
are
substances
,
which
quantitatively
changes
in
serum
,
during
the
tumor
development
,
one
such
tumor
marker
is
serum
β
2
-
microglobulin
(
β
2
-
m
)
.
The
aim
of
this
study
was
to
establish
the
role
of
β
2
-
m
as
a
biochemical
parameter
for
diagnosis
and
prognosis
of
oral
carcinoma
by
estimation
of
serum
β
2
-
m
levels
in
potentially
malignant
lesions
,
conditions
,
and
oral
squamous
cell
carcinoma
.
The
study
was
carried
out
on
48
subjects
(
16
control
,
8
oral
submucous
fibrosis
,
8
oral
leukoplakia
,
and
16
oral
squamous
cell
carcinoma
patients
of
different
stages
)
,
conducted
at
department
of
Oral
Medicine
,
Kothiwal
Dental
College
,
Moradabad
,
India
.
Under
aseptic
precautions
,
5
ml
venous
blood
was
drawn
and
serum
was
separated
.
Estimation
of
β
2
-
m
level
in
serum
was
carried
out
by
enzyme
linked
immunosorbent
assay
.
The
data
were
analyzed
by
using
the
statistical
package
for
social
sciences
(
SPSS
17
.
0
)
software
.
Cases
and
controls
were
tested
for
statistical
significance
with
one
-way
ANOVA
with
post-hoc
Tukey
's
HSD
.
Values
of
P
<
0
.
05
were
considered
significant
.
The
mean
serum
β
2
-
m
level
in
the
control
group
was
1
.
173
±
0
.
059
,
in
potentially
malignant
lesions
/
conditions
group
was
1
.
688
±
0
.
137
and
in
oral
squamous
cell
carcinoma
group
was
2
.
835
±
0
.
0313
.
This
progressive
increase
in
serum
β
2
-
m
level
was
found
to
be
highly
significant
(
P
value
<
0
.
001
)
.
Results
of
Receiver
operating
characteristic
analysis
showed
β
2
-
m
as
a
100
%
sensitive
and
specific
biomarker
for
oral
squamous
cell
carcinoma
.
The
present
study
establishes
β
2
-
m
as
a
specific
biological
tumor
marker
for
diagnostic
and
prognostic
evaluation
of
oral
squamous
cell
carcinoma
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated