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Estimation of serum β2-microglobulin in potentially malignant disorders and squamous cell carcinoma of the oral cavity: A clinicopathological study.
[oral submucous fibrosis]
Tumor
markers
are
substances
,
which
quantitatively
changes
in
serum
,
during
the
tumor
development
,
one
such
tumor
marker
is
serum
β
2
-
microglobulin
(
β
2
-
m
)
.
The
aim
of
this
study
was
to
establish
the
role
of
β
2
-
m
as
a
biochemical
parameter
for
diagnosis
and
prognosis
of
oral
carcinoma
by
estimation
of
serum
β
2
-
m
levels
in
potentially
malignant
lesions
,
conditions
,
and
oral
squamous
cell
carcinoma
.
The
study
was
carried
out
on
48
subjects
(
16
control
,
8
oral
submucous
fibrosis
,
8
oral
leukoplakia
,
and
16
oral
squamous
cell
carcinoma
patients
of
different
stages
)
,
conducted
at
department
of
Oral
Medicine
,
Kothiwal
Dental
College
,
Moradabad
,
India
.
Under
aseptic
precautions
,
5
ml
venous
blood
was
drawn
and
serum
was
separated
.
Estimation
of
β
2
-
m
level
in
serum
was
carried
out
by
enzyme
linked
immunosorbent
assay
.
The
data
were
analyzed
by
using
the
statistical
package
for
social
sciences
(
SPSS
17
.
0
)
software
.
Cases
and
controls
were
tested
for
statistical
significance
with
one
-way
ANOVA
with
post-hoc
Tukey
's
HSD
.
Values
of
P
<
0
.
05
were
considered
significant
.
The
mean
serum
β
2
-
m
level
in
the
control
group
was
1
.
173
±
0
.
059
,
in
potentially
malignant
lesions
/
conditions
group
was
1
.
688
±
0
.
137
and
in
oral
squamous
cell
carcinoma
group
was
2
.
835
±
0
.
0313
.
This
progressive
increase
in
serum
β
2
-
m
level
was
found
to
be
highly
significant
(
P
value
<
0
.
001
)
.
Results
of
Receiver
operating
characteristic
analysis
showed
β
2
-
m
as
a
100
%
sensitive
and
specific
biomarker
for
oral
squamous
cell
carcinoma
.
The
present
study
establishes
β
2
-
m
as
a
specific
biological
tumor
marker
for
diagnostic
and
prognostic
evaluation
of
oral
squamous
cell
carcinoma
.
Diseases
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Diseases presenting
"conditions"
symptom
oral submucous fibrosis
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