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Cytomorphometric analysis of oral submucous fibrosis and leukoplakia using methyl green-pyronin Y, Feulgen staining and exfoliative brush cytology.
[oral submucous fibrosis]
The
incidence
of
potentially
malignant
oral
pathology
such
as
leukoplakia
,
oral
submucous
fibrosis
and
squamous
cell
carcinoma
has
increased
in
India
.
We
investigated
whether
cytoplasmic
diameter
,
nuclear
diameter
and
nucleus
:
cytoplasm
ratio
in
exfoliative
cytology
are
reliable
indicators
of
potentially
malignant
lesions
.
We
also
investigated
methyl
green-pyronin
Y
and
Feulgen
staining
as
simple
time
saving
and
cost
effective
staining
techniques
for
diagnostic
exfoliative
cytology
.
Cell
and
nuclear
diameters
of
squamous
cells
of
normal
buccal
mucosa
,
oral
leukoplakia
and
oral
submucous
fibrosis
were
measured
using
an
ocular
micrometer
disc
.
The
nucleus
:
cytoplasm
ratios
in
pathological
cells
were
compared
to
age
,
sex
and
site
matched
controls
.
We
found
a
significant
reduction
in
the
mean
cytoplasmic
and
nuclear
diameter
in
the
experimental
groups
compared
to
normal
controls
.
Methyl
green-pyronin
Y
stained
smears
were
clearer
than
Feulgen
stained
cells
.
We
suggest
that
a
decreased
mean
cytoplasmic
diameter
of
exfoliated
buccal
mucosal
cells
could
serve
as
an
early
indicator
of
dysplastic
change
in
lesions
that
otherwise
appear
benign
.
Methyl
green-pyronin
Y
may
be
useful
for
identifying
premalignant
and
malignant
transformations
before
a
lesion
is
visible
.
The
simplicity
of
the
technique
makes
its
routine
use
feasible
.
Diseases
Validation
Diseases presenting
"cost effective staining techniques for diagnostic exfoliative cytology"
symptom
oral submucous fibrosis
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