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[Changes of miRNA after oral submucous fibrosis co-cultured with Salvia and low-dose prednisolone].
[oral submucous fibrosis]
To
explore
and
analyze
the
the
expression
change
of
miRNA
associated
with
oral
submucous
fibrosis
(
OSF
)
treated
by
the
Salvia
combined
with
law-dose
prednisolone
.
Ten
pairs
of
tissues
from
patients
with
typical
early
or
advanced
stage
clinical
pathological
features
of
OSF
and
their
paired
normal
tissues
(
internal
control
)
,
were
selected
respectively
.
The
miRNA
expression
profiles
between
the
OSF
and
its
paired
controls
were
compared
by
the
Affymetrix
analysis
.
The
primary
normal
oral
mucous
cells
were
cultured
in
arecoline
(
50
μg
/
mL
)
for
3
,
6
,
12
d
(
0
d
ser
ved
as
cont
rol
)
,
and
the
primary
OSF-fibroblast
cells
were
cultured
with
Salvia
(
90
mg
/
mL
)
combined
with
low
-dose
prednisolone
for
12
,
24
,
36
h
(
0
h
served
as
control
)
.
The
differential
expression
of
miRNA
was
detected
.
Arecoline
induced
the
expression
changes
of
miRNAs
in
normal
mucosal
cells
.
Salvia
combined
with
low
doses
of
prednisolone
reversed
the
related
miRNA
expression
.
M
iRNAs
play
an
essential
role
in
the
occurrence
and
development
of
OSF
.
Salvia
combined
with
low
-dose
prednisolone
can
reverse
the
expression
of
related
miRNAs
in
OSF
cells
.
