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A study on mast cell number and lipid profile in oral submucous fibrosis.
[oral submucous fibrosis]
Prevention
of
oral
precancer
is
most
desirable
and
should
take
precedence
over
its
diagnosis
and
therapy
.
As
both
,
mast
cell
counts
in
connective
tissue
and
serum
lipids
are
altered
in
Oral
Submucous
Fibrosis
(
OSF
)
,
so
study
of
both
the
factors
is
vitally
important
in
OSF
.
A
total
of
50
persons
were
included
in
the
study
of
which
40
were
OSF
patients
and
10
controls
.
Tissue
sections
and
blood
samples
were
collected
for
mast
cell
count
and
lipid
profile
estimation
for
both
OSF
patients
and
controls
.
Mean
mast
cells
in
all
grades
of
OSF
were
higher
as
compared
to
apparently
normal
appearing
oral
mucosa
but
as
severity
of
OSF
increases
(
from
Grade
II
to
Grade
IV
)
,
count
of
Mast
cell
decreases
.
Further
,
the
mean
mast
cells
in
OSF
Grade
II
,
III
and
IV
groups
were
found
95
.
5
%
,
93
.
8
%
and
92
.
2
%
higher
respectively
as
compared
to
normal
(
highly
significant
for
all
the
groups
p
<
0
.
001
)
.
The
mean
serum
lipid
profile
of
OSF
groups
was
comparatively
lower
than
age
and
sex
matched
healthy
controls
but
was
highly
significant
for
all
the
groups
(
p
<
0
.
001
)
.
Thus
,
it
can
be
said
that
in
the
present
study
serum
lipid
profile
decreases
in
OSF
patients
and
mast
cell
count
is
increased
when
compared
with
apparently
normal
appearing
mucosa
but
with
the
advancement
of
the
grades
mast
cell
number
decreases
in
tissue
sections
of
OSF
.
It
can
be
suggested
that
biochemical
and
histological
assessment
of
OSF
patients
may
help
in
earlier
diagnosis
and
/
or
prognosis
of
this
disease
.
