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Evaluation of plasma fibrinogen degradation products and total serum protein concentration in oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
is
a
potentially
malignant
disorder
with
a
multifactorial
etiology
.
Malnutrition
is
a
major
problem
for
the
inhabitants
of
most
countries
where
OSMF
is
prevalent
.
Recently
,
a
new
direction
in
the
etiopathogenesis
was
provided
by
the
identification
of
fibrinogen
degradation
products
(
FDP
)
in
the
plasma
of
OSMF
patients
.
To
assess
the
role
of
FDP
in
the
etiology
of
OSMF
and
to
correlate
with
the
nutritional
status
by
evaluating
the
total
serum
protein
level
.
The
study
also
determines
to
evaluate
the
correlation
between
the
levels
of
plasma
FDP
with
respect
to
the
staging
and
grading
of
OSMF
.
Correlation
between
the
levels
of
Total
Serum
Protein
(
TSP
)
with
respect
to
the
staging
and
grading
of
OSMF
was
also
evaluated
.
The
study
included
30
cases
clinically
and
histopathologically
diagnosed
as
oral
submucous
fibrosis
.
The
FDP
levels
were
assessed
using
both
qualitative
and
semi
quantitative
method
as
supplied
by
'
Tulip
Diagnostics
(
P
)
Ltd
.
Total
Serum
Protein
(
TSP
)
estimation
was
done
by
Biuret
method
using
Liquixx
Protein
kit
by
Erba
,
Manheim
.
The
study
indicates
that
in
qualitative
assessment
of
FDP
only
14
subjects
showed
the
presence
of
FDP
levels
>
200
ng
/
ml
.
In
semiquantitative
assessment
there
is
no
significant
association
between
varying
clinical
stages
and
histopathological
grades
and
FDP
levels
.
Total
serum
Protein
level
showed
a
marginal
increase
in
all
subjects
.
The
study
revealed
a
positive
correlation
between
FDP
and
TSP
in
all
OSMF
subjects
.
A
larger
sample
size
which
would
be
a
better
representation
of
the
population
and
the
use
of
different
methods
which
have
higher
sensitivities
and
specificities
to
evaluate
FDP
level
and
detailed
fractional
analysis
of
protein
along
with
immunoglobulin
profiling
would
facilitate
in
attaining
more
conclusive
results
.