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Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders.
[oral submucous fibrosis]
Oral
cancers
can
be
preceded
by
clinically
evident
oral
potentially
malignant
disorders
(
OPMDs
)
.
The
current
study
evaluated
the
rate
and
the
time
of
malignant
transformation
in
the
various
OPMDs
in
a
cohort
of
patients
from
southern
Taiwan
.
Parameters
possibly
indicative
for
malignant
transformation
of
OPMDs
,
such
as
epidemiological
and
etiological
factors
,
and
clinical
and
histopathological
features
were
also
described
.
We
followed-up
5071
patients
with
OPMDs-epithelial
dysplasia
with
oral
submucous
fibrosis
,
epithelial
dysplasia
with
hyperkeratosis
/
epithelial
hyperplasia
,
hyperkeratosis
/
epithelial
hyperplasia
,
oral
submucous
fibrosis
,
lichen
planus
,
and
verrucous
hyperplasia
-between
2001
and
2010
for
malignant
transformation
.
Two
hundred
nineteen
of
these
5071
OPMD
patients
(
202
men
,
17
women
;
mean
age
:
51
.
25
years
;
range
:
30
-
81
years
)
developed
oral
cancers
(
179
squamous
cell
carcinomas
;
40
verrucous
carcinomas
)
in
the
same
sites
as
the
initial
lesions
at
least
6
months
after
their
initial
biopsies
.
The
overall
transformation
rate
was
4
.
32
%
(
mean
duration
of
transformation
:
33
.
56
months
;
range
:
6
-
67
months
)
.
Additionally
,
the
mean
time
of
malignant
transformation
was
significantly
shorter
for
lesions
with
than
without
epithelial
dysplasia
.
The
risk
of
malignant
transformation
was
1
.
89
times
higher
for
epithelially
dysplastic
than
non-
dysplastic
lesions
.
The
anatomical
site
of
OPMD
and
the
presence
of
epithelial
dysplasia
were
significantly
associated
with
malignant
transformation
.
The
hazard
rate
ratio
was
1
.
87
times
larger
for
tongue
lesions
than
for
buccal
lesions
.
Patients
with
OPMDs
require
long
-term
follow
up
.
Diseases
Validation
Diseases presenting
"malignant transformation"
symptom
achondroplasia
adrenal incidentaloma
child syndrome
cholangiocarcinoma
cutaneous mastocytosis
epidermolysis bullosa simplex
esophageal adenocarcinoma
liposarcoma
oral submucous fibrosis
severe combined immunodeficiency
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