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Serum lipid profile in patients with oral cancer and oral precancerous conditions.
[oral submucous fibrosis]
The
present
study
was
undertaken
to
estimate
and
compare
the
levels
of
plasma
total
cholesterol
(
TC
)
,
low
density
lipoprotein
(
LDL
)
,
high
density
lipoprotein
(
HDL
)
,
very
low
density
lipoprotein
(
VLDL
)
and
triglycerides
in
patients
with
oral
precancerous
lesions
/
conditions
,
oral
cancer
and
normal
subjects
.
The
study
comprised
of
60
patients
with
oral
precancerous
lesions
/
conditions
,
60
patients
with
oral
cancer
and
a
control
group
of
60
healthy
individuals
.
The
diagnosis
of
oral
precancerous
lesions
/
conditions
and
oral
cancer
was
confirmed
histopathologically
.
Under
aseptic
condition
5
ml
venous
blood
of
overnight
fasting
patient
was
withdrawn
from
each
individual
.
Serum
was
separated
by
centrifugation
and
plasma
levels
of
TC
,
LDL
,
HDL
,
VLDL
and
triglycerides
were
estimated
.
Descriptive
statistical
analysis
has
been
carried
out
in
the
present
study
.
Analysis
of
variance
has
been
used
to
find
the
significance
of
study
parameters
between
three
or
more
groups
of
patients
,
Post-hoc
test
as
Tukey
has
been
used
to
find
the
pair
wise
significance
.
Significance
is
assessed
at
5
%
level
of
significance
.
Statistically
significant
decrease
in
levels
of
plasma
TC
,
LDL
,
HDL
,
VLDL
and
triglycerides
was
observed
in
the
precancerous
and
cancerous
groups
as
compared
to
the
control
group
.
On
comparison
between
precancerous
and
cancerous
groups
,
significant
decrease
was
observed
in
cancerous
group
.
The
change
in
lipid
levels
may
have
an
early
diagnostic
or
prognostic
role
in
the
oral
premalignant
lesions
/
conditions
and
oral
cancer
.
The
presence
of
decreased
plasma
lipid
profile
should
increase
the
suspicion
of
these
lesions
to
be
investigated
further
.
Diseases
Validation
Diseases presenting
"total cholesterol"
symptom
acute rheumatic fever
adrenal incidentaloma
aromatase deficiency
classical phenylketonuria
cystinuria
oral submucous fibrosis
phenylketonuria
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