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Estimation of serum lipids in patients with Oral Submucous Fibrosis in India.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
is
the
most
prevalent
precancerous
condition
in
India
.
Low
levels
of
lipids
serves
as
a
marker
and
prognostic
indicator
in
the
early
detection
of
oral
precancerous
and
cancerous
states
.
In
spite
of
the
high
prevalence
and
its
potential
to
undergo
malignant
transformation
,
this
condition
has
not
widely
been
investigated
with
respect
to
the
serum
lipid
levels
.
In
the
present
study
,
an
attempt
was
made
to
analyze
the
complete
serum
lipid
profile
,
total
cholesterol
(
TC
)
,
triglycerides
(
TG
)
,
high
density
lipoprotein
(
HDL
)
cholesterol
,
low
density
lipoprotein
(
LDL
)
cholesterol
and
very
low
density
lipoprotein
(
VLDL
)
cholesterol
in
OSMF
and
controls
.
The
study
was
conducted
in
45
clinically
and
histopathologically
diagnosed
cases
of
OSMF
and
45
age
and
sex
matched
controls
.
The
complete
lipid
profile
including
TC
,
TG
,
HDL
cholesterol
,
LDL
cholesterol
and
VLDL
cholesterol
was
analyzed
.
The
serum
lipid
levels
were
significantly
lower
in
the
patients
with
OSMF
than
in
the
controls
.
When
the
values
were
compared
between
different
disease
stages
,
the
maximum
reduction
of
lipids
was
evident
for
stage
3
OSMF
.
From
the
present
results
,
it
is
evident
that
the
level
of
serum
lipids
decreases
with
progression
of
the
disease
.
From
these
findings
,
it
appears
that
the
decrease
in
the
lipid
levels
may
be
considered
as
a
useful
marker
in
the
early
diagnosis
of
oral
premalignant
condition
like
OSMF
.
Key
words
:
Oral
submucous
fibrosis
,
lipids
,
premalignant
condition
.
Diseases
Validation
Diseases presenting
"early diagnosis"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
allergic bronchopulmonary aspergillosis
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
coats disease
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
locked-in syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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