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Estimation of serum lipids in patients with Oral Submucous Fibrosis in India.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
is
the
most
prevalent
precancerous
condition
in
India
.
Low
levels
of
lipids
serves
as
a
marker
and
prognostic
indicator
in
the
early
detection
of
oral
precancerous
and
cancerous
states
.
In
spite
of
the
high
prevalence
and
its
potential
to
undergo
malignant
transformation
,
this
condition
has
not
widely
been
investigated
with
respect
to
the
serum
lipid
levels
.
In
the
present
study
,
an
attempt
was
made
to
analyze
the
complete
serum
lipid
profile
,
total
cholesterol
(
TC
)
,
triglycerides
(
TG
)
,
high
density
lipoprotein
(
HDL
)
cholesterol
,
low
density
lipoprotein
(
LDL
)
cholesterol
and
very
low
density
lipoprotein
(
VLDL
)
cholesterol
in
OSMF
and
controls
.
The
study
was
conducted
in
45
clinically
and
histopathologically
diagnosed
cases
of
OSMF
and
45
age
and
sex
matched
controls
.
The
complete
lipid
profile
including
TC
,
TG
,
HDL
cholesterol
,
LDL
cholesterol
and
VLDL
cholesterol
was
analyzed
.
The
serum
lipid
levels
were
significantly
lower
in
the
patients
with
OSMF
than
in
the
controls
.
When
the
values
were
compared
between
different
disease
stages
,
the
maximum
reduction
of
lipids
was
evident
for
stage
3
OSMF
.
From
the
present
results
,
it
is
evident
that
the
level
of
serum
lipids
decreases
with
progression
of
the
disease
.
From
these
findings
,
it
appears
that
the
decrease
in
the
lipid
levels
may
be
considered
as
a
useful
marker
in
the
early
diagnosis
of
oral
premalignant
condition
like
OSMF
.
Key
words
:
Oral
submucous
fibrosis
,
lipids
,
premalignant
condition
.
Diseases
Validation
Diseases presenting
"low levels"
symptom
22q11.2 deletion syndrome
adrenal incidentaloma
adrenomyeloneuropathy
aromatase deficiency
benign recurrent intrahepatic cholestasis
cadasil
congenital adrenal hyperplasia
congenital diaphragmatic hernia
esophageal carcinoma
hodgkin lymphoma, classical
liposarcoma
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
neonatal adrenoleukodystrophy
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
primary effusion lymphoma
sneddon syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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