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Estimation of serum lipids in patients with Oral Submucous Fibrosis in India.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
is
the
most
prevalent
precancerous
condition
in
India
.
Low
levels
of
lipids
serves
as
a
marker
and
prognostic
indicator
in
the
early
detection
of
oral
precancerous
and
cancerous
states
.
In
spite
of
the
high
prevalence
and
its
potential
to
undergo
malignant
transformation
,
this
condition
has
not
widely
been
investigated
with
respect
to
the
serum
lipid
levels
.
In
the
present
study
,
an
attempt
was
made
to
analyze
the
complete
serum
lipid
profile
,
total
cholesterol
(
TC
)
,
triglycerides
(
TG
)
,
high
density
lipoprotein
(
HDL
)
cholesterol
,
low
density
lipoprotein
(
LDL
)
cholesterol
and
very
low
density
lipoprotein
(
VLDL
)
cholesterol
in
OSMF
and
controls
.
The
study
was
conducted
in
45
clinically
and
histopathologically
diagnosed
cases
of
OSMF
and
45
age
and
sex
matched
controls
.
The
complete
lipid
profile
including
TC
,
TG
,
HDL
cholesterol
,
LDL
cholesterol
and
VLDL
cholesterol
was
analyzed
.
The
serum
lipid
levels
were
significantly
lower
in
the
patients
with
OSMF
than
in
the
controls
.
When
the
values
were
compared
between
different
disease
stages
,
the
maximum
reduction
of
lipids
was
evident
for
stage
3
OSMF
.
From
the
present
results
,
it
is
evident
that
the
level
of
serum
lipids
decreases
with
progression
of
the
disease
.
From
these
findings
,
it
appears
that
the
decrease
in
the
lipid
levels
may
be
considered
as
a
useful
marker
in
the
early
diagnosis
of
oral
premalignant
condition
like
OSMF
.
Key
words
:
Oral
submucous
fibrosis
,
lipids
,
premalignant
condition
.
Diseases
Validation
Diseases presenting
"low density lipoprotein"
symptom
oral submucous fibrosis
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