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Expression and location of phospho-Artemis (Serine516) in hair follicles during induced growth of mouse hair.
[omenn syndrome]
Artemis
has
been
implicated
in
having
a
role
in
NHEJ
,
and
it
is
also
a
multifunctional
protein
.
Previous
studies
have
found
Omenn
syndrome
-like
phenotype
due
to
Artemis
mutations
and
associated
with
alopecia
.
As
Artemis
phosphorylation
in
its
c-terminus
including
Serine
516
is
prerequisite
for
the
Artemis
endonuclease
reaction
,
we
postulate
that
Artemis
(
Serine
516
)
may
be
expressed
in
hair
follicle
and
relate
to
hair
cycling
.
In
this
study
,
hair
growth
in
C
5
7
BL
/
6
mice
was
induced
by
plucking
the
telogen
hair
on
the
back
.
Expression
of
Artemis
(
Serine
516
)
in
hair
follicles
during
the
hair
growth
cycle
was
evaluated
by
immunofluorescence
using
cryosections
and
a
specific
polyclonal
anti-
Artemis
(
Serine
516
)
immunoglobulin
G
(
IgG
)
antibody
.
It
was
detected
in
germ
cells
,
cap
,
and
club
hair
adjoining
the
epidermis
in
telogen
.
In
anagen
II
,
intense
staining
for
Artemis
(
Serine
516
)
was
found
in
the
whole
interfollicular
epidermis
,
and
in
strand
keratinocytes
.
In
anagen
IV
,
intense
staining
for
Artemis
(
Serine
516
)
was
detected
in
basal
cells
and
upper
of
outer
root
sheath
(
ORS
)
and
inner
root
sheath
(
IRS
)
.
But
only
upper
ORS
and
lower
medulla
were
stained
positive
in
anagen
VI
.
Upper
ORS
and
lower
cortex
were
positively
stained
with
Artemis
(
Serine
516
)
in
catagen
.
Based
on
the
phenomenon
that
the
expression
of
Artemis
(
Serine
516
)
in
mid-anagen
and
mature
anagen
was
stronger
than
that
in
telogen
and
catagen
,
we
suggest
it
may
take
roles
in
induced
growth
of
mouse
hair
.
Diseases
Validation
Diseases presenting
"basal cells"
symptom
epidermolysis bullosa simplex
kindler syndrome
lamellar ichthyosis
omenn syndrome
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