Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Effects of body-color mutations on vitality: an attempt to establish easy-to-breed see-through medaka strains by outcrossing.
[oculocutaneous albinism]
"
See-through
"
strains
of
medaka
are
unique
tools
for
experiments
:
their
skin
is
transparent
,
and
their
internal
organs
can
be
externally
monitored
throughout
life
.
However
,
see-through
fish
are
less
vital
than
normally
pigmented
wild-
type
fish
,
which
allows
only
skilled
researchers
to
make
the
most
of
their
advantages
.
Expecting
that
hybrid
vigor
(
heterosis
)
would
increase
the
vitality
,
we
outcrossed
two
see-through
strains
(
SK
(
2
)
and
STIII
)
with
a
genetically
distant
wild-
type
strain
(
HNI
)
.
Fish
with
the
see-through
phenotypes
were
successfully
restored
in
the
F
2
generation
and
maintained
as
closed
colonies
.
We
verified
that
genomes
of
these
hybrid
see-through
strains
actually
consisted
of
approximately
50
%
HNI
and
approximately
50
%
SK
(
2
)
or
STIII
alleles
,
but
we
could
not
obtain
evidence
supporting
improved
survival
of
larvae
or
fecundity
of
adults
,
at
least
under
our
breeding
conditions
.
We
also
found
that
four
of
the
five
see-through
mutations
(
b
(
g
8
)
,
i-
3
,
gu
,
and
il
-
1
but
not
lf
)
additively
decrease
viability
.
Given
that
heterosis
could
not
overwhelm
the
viability-reducing
effects
of
the
see-through
mutations
,
easy-
to
-breed
see-through
strains
will
only
be
established
by
other
methods
such
as
conditional
gene
targeting
or
screening
of
new
body-color
mutations
that
do
not
reduce
viability
.
Diseases
Validation
Diseases presenting
"which allows only skilled researchers to make the most of their advantages"
symptom
oculocutaneous albinism
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom