Phenotypic differences between mdx black mice and mdx albino mice. Comparison of cytokine levels in the blood.

[oculocutaneous albinism]

In mdx mice , mutation in the muscle protein dystrophin gene results in the development of chronic degeneration of the muscle tissue . We performed a comparative analysis of blood cytokine levels in mdx mice , classical black mice and mice with additional genetic defect responsible for the manifestations of oculocutaneous albinism . In mdx albino mice , the total pool of cytokines (IL -10 , IL -6 , IL -5 , IL -2 , IL -1 α , IL -4 , IL -17 , granulocyte-macrophage growth factor , TNF -α , and IFN-γ ) was increased . This increase was not associated with selective release of one of the above cytokines into the blood . The fraction of pro-inflammatory cytokines (IL -6 , IL -1 α , TNF -α ) was increased in the total pool and the percentage of antiinflammatory cytokines (IL -4 ) was reduced . Changes in cytokine pool probably reflect the differences in the severity of the pathological process in the muscle tissue of both genetic variations of mdx mice .

Diseases
Validation

Diseases presenting "growth factor" symptom

22q11.2 deletion syndrome

achondroplasia

adrenal incidentaloma

aniridia

cadasil

cholangiocarcinoma

coats disease

dedifferentiated liposarcoma

dentin dysplasia

dentinogenesis imperfecta

dystrophic epidermolysis bullosa

esophageal carcinoma

esophageal squamous cell carcinoma

hodgkin lymphoma, classical

holt-oram syndrome

inclusion body myositis

kallmann syndrome

krabbe disease

liposarcoma

lymphangioleiomyomatosis

oculocutaneous albinism

oral submucous fibrosis

pleomorphic liposarcoma

primary effusion lymphoma

primary hyperoxaluria type 1

severe combined immunodeficiency

systemic capillary leak syndrome

von hippel-lindau disease

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

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