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[Pathogenesis and treatment of brachial plexus neuritis].
[neuralgic amyotrophy]
Neuralgic
amyotrophy
(
NA
,
also
known
as
Parsonage-
Turner
syndrome
)
is
a
distinct
peripheral
nervous
system
(
PNS
)
disorder
,
characterized
by
sudden
attacks
of
severe
neuropathic
pain
usually
in
the
shoulder
and
/
or
arm
.
The
neuralgia
commonly
disappears
after
a
few
days
to
weeks
,
and
consequently
patchy
paresis
with
amyotrophy
appears
.
The
available
evidence
suggests
that
NA
is
essentially
idiopathic
immune-mediated
neuritis
of
the
brachial
plexus
,
and
also
has
a
complex
pathogenesis
that
includes
an
underlying
predisposition
,
susceptibility
to
dysfunction
of
some
PNS
structure
,
and
a
trigger
for
the
attacks
,
such
as
viral
infection
,
vaccination
,
trauma
,
surgery
,
and
strenuous
exercise
.
Genetic
factors
also
contribute
to
the
pathogenesis
of
NA
,
and
thus
,
this
disorder
occurs
in
both
idiopathic
and
hereditary
forms
,
but
hereditary
one
is
considered
to
be
10
times
less
common
than
idiopathic
one
.
NA
has
been
considered
to
be
self-limiting
,
benign
disorder
showing
good
recovery
without
specific
treatments
.
However
,
recent
studies
have
indicated
that
the
long
-term
prognosis
of
NA
is
less
favorable
than
has
been
assumed
.
In
2009
,
a
Cochrane
review
identified
one
open
label
,
retrospective
series
,
the
results
of
which
suggested
that
administration
of
corticosteroids
in
the
acute
phase
of
NA
could
shorten
the
duration
of
painful
symptoms
and
also
accelerate
recovery
in
some
patients
.
We
recently
have
reported
that
intravenous
immunoglobulin
(
IVIg
)
with
methylpredonisolone
pulse
therapy
is
effective
for
motor
impairment
of
NA
.
Diseases
Validation
Diseases presenting
"pain"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
aniridia
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pleomorphic liposarcoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
scrub typhus
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
trochlear dysplasia
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wolf-hirschhorn syndrome
This symptom has already been validated