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A random Abstract
Our Project
Our Team
Comprehensive chromosome analysis of blastocysts before implantation using array CGH.
[monosomy 21]
Chromosomal
abnormalities
are
common
in
embryos
produced
in
vitro
and
cause
implantation
failure
,
miscarriage
,
and
serious
medical
problems
in
infants
.
Because
preimplantation
genetic
screening
(
PGS
)
is
increasingly
being
used
to
detect
aneuploidy
in
embryos
with
the
purpose
of
improving
implantation
rates
after
IVF
(
in
vitro
fertilization
)
,
we
aimed
to
validate
the
usefulness
of
array
CGH
for
the
preimplantation
genetic
screening
(
PGS
)
of
embryos
at
the
blastocyst
stage
of
development
.
A
total
of
150
blastocysts
were
biopsied
from
couples
undergoing
IVF
and
analyzed
using
array
CGH
.
We
found
that
54
.
5
%
(
73
/
134
)
of
the
blastocysts
were
euploid
embryos
,
whereas
45
.
5
%
of
the
embryos
(
61
/
134
)
had
chromosomal
abnormalities
.
Multiple
chromosome
abnormality
was
most
frequently
observed
(
34
.
4
%
)
,
and
dual
aneuploidy
was
observed
in
26
.
2
%
of
the
embryos
.
Monosomy
(
21
.
3
%
)
appeared
more
frequently
than
trisomy
(
18
%
)
.
Chromosomal
microarray
analysis
provided
clinically
significant
cytogenetic
information
regarding
the
frequency
and
variety
of
chromosomal
abnormalities
observed
in
embryos
at
the
blastocyst
stage
,
suggesting
that
this
is
a
useful
tool
for
comprehensive
aneuploidy
screening
in
IVF
.
