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[Analysis of clinical features and allergic status of asthmatic patients with positive serum mycosis-specific IgE].
[allergic bronchopulmonary aspergillosis]
To
improve
understanding
of
the
clinical
characteristics
and
diagnosis
of
allergic
bronchopulmonary
mycosis
(
ABPM
)
.
We
retrospectively
analyzed
the
clinical
data
,
including
clinical
symptoms
,
laboratory
tests
,
pulmonary
function
tests
and
chest
CT
imaging
of
95
asthmatic
patients
with
positive
serum
mycosis-
specific
IgE
from
January
2010
to
September
2012
in
Zhongshan
Hospital
Affiliated
to
Fudan
University
.
Of
the
95
patients
,
59
cases
met
the
diagnostic
criteria
of
ABPM
.
There
were
34
males
and
25
females
,
with
a
mean
age
of
(
53
±
4
)
years
and
a
duration
of
asthma
for
(
21
±
4
)
years
.
Thirty
-
six
cases
showed
mycosis
hypersensitivity
(
MH
)
.
There
were
10
males
and
26
females
,
with
a
mean
age
of
(
46
±
6
)
years
and
a
duration
of
asthma
for
(
16
±
5
)
years
.
Clinical
symptoms
such
as
wheeze
(
52
vs
21
,
χ
(
2
)
=
11
.
159
,
P
=
0
.
001
)
,
cough
(
54
vs
27
,
χ
(
2
)
=
4
.
859
,
P
=
0
.
030
)
and
expectoration
(
43
vs
9
,
χ
(
2
)
=
25
.
731
,
P
=
0
.
000
)
were
more
common
in
the
ABPM
group
compared
to
the
MH
group
.
In
the
ABPM
group
,
58
were
A
.
fumigatus-
specific
IgE
antibody
positive
,
34
Penicillium-
specific
IgE
antibody
positive
and
1
only
Penicillium-
specific
IgE
antibody
positive
.
W
hile
in
the
MH
group
,
15
were
A
.
fumigatus-
specific
IgE
antibody
positive
,
24
Penicillium-
specific
IgE
antibody
positive
and
17
only
Penicillium-
specific
IgE
antibody
positive
.
In
the
ABPM
group
,
the
percentage
of
positive
fumigatus-
specific
IgE
antibody
was
higher
(
58
vs
15
,
χ
(
2
)
=
24
.
500
,
P
=
0
.
000
)
,
while
the
percentages
of
dermatophagoides
pteronyssinus
(
21
vs
20
,
χ
(
2
)
=
3
.
632
,
P
=
0
.
045
)
and
Dermatophagoides
farinae
(
17
vs
21
,
χ
(
2
)
=
8
.
118
,
P
=
0
.
004
)
were
lower
.
Total
serum
IgE
[
(
4395
±
1437
)
IU
/
ml
vs
(
276
±
133
)
IU
/
ml
,
T
=
4
.
384
,
P
=
0
.
000
]
,
peripheral
eosinophil
percentage
[
(
12
.
56
±
1
.
20
)
%
vs
(
1
.
30
±
0
.
15
)
%
,
t
=
8
.
175
,
P
=
0
.
000
]
and
count
[
(
2
.
09
±
0
.
43
)
×
10
(
9
)
/
L
vs
(
0
.
19
±
0
.
04
)
×
10
(
9
)
/
L
,
t
=
7
.
032
,
P
=
0
.
000
]
were
higher
in
the
ABPM
group
as
compared
to
the
MH
group
.
FEV
1
%
slightly
declined
in
the
ABPM
group
[
(
70
.
2
±
2
.
3
)
%
vs
(
78
.
3
±
3
.
2
%
)
%
,
t
=
2
.
011
,
P
=
0
.
038
]
.
Forty
-
one
cases
(
69
.
50
%
)
had
central
bronchiectasis
and
18
(
30
.
50
%
)
had
mucus
plugs
in
the
ABPM
group
.
Chest
CT
scan
was
normal
in
the
MH
group
.
ABPM
is
common
in
asthmatic
patients
but
has
long
been
underestimated
and
misdiagnosed
.
Efforts
need
to
be
intensified
to
improve
the
awareness
among
clinicians
for
early
diagnosis
and
treatment
of
the
disease
.
Diseases
Validation
Diseases presenting
"early diagnosis"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
allergic bronchopulmonary aspergillosis
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
coats disease
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
locked-in syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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