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Does maternal drug ingestion cause megacystis microcolon intestinal hypoperistalsis syndrome? I. Clomiphene trial.
[megacystis-microcolon-intestinal hypoperistalsis syndrome]
Megacystis
Microcolon
Intestinal
Hypoperistalsis
Syndrome
(
MMIHS
)
is
a
congenital
and
lethal
disease
,
and
the
etiology
of
the
disease
is
not
clear
.
It
is
speculated
that
maternal
ingestion
of
some
drugs
during
pregnancy
may
be
an
etiologic
factor
.
In
this
study
we
aimed
to
investigate
the
effect
of
maternal
ingestion
of
clomiphene
on
fetal
bladder
and
colon
in
pregnant
rats
.
We
separated
animals
into
a
control
group
including
14
rats
and
a
clomiphene
group
with
30
rats
.
Nothing
was
given
to
the
control
group
during
pregnancy
.
Two
mg
/
kg
/
day
clomiphene
intraperitoneally
was
given
to
the
study
group
from
the
6
th
to
12
th
day
of
pregnancy
.
All
of
them
were
sacrificed
on
the
20
th
day
of
pregnancy
.
Histopathological
examination
of
the
fetal
colon
and
bladder
was
performed
.
In
the
clomiphene
group
a
significant
decrease
in
the
thickness
of
the
bladder
wall
,
an
increase
in
bladder
epithelium
,
an
increase
in
muscle
atrophy
of
the
colon
and
bladder
wall
,
an
increase
in
vacuoler
degeneration
of
the
muscles
of
the
bladder
and
colon
wall
,
a
decrease
in
ganglion
cell
numbers
in
the
myenteric
plexus
of
the
bladder
and
a
decrease
in
the
thickness
of
the
bladder
tunica
muscularis
were
determined
.
In
our
rat
model
we
found
histological
structural
changes
in
the
rats
'
colon
and
bladder
walls
as
a
result
of
using
clomiphene
on
days
6
-
12
of
pregnancy
;
a
similar
pathological
finding
to
those
found
in
some
of
the
MMIHS
patients
'
colons
and
bladders
.
Diseases
Validation
Diseases presenting
"and the etiology of the disease is not clear"
symptom
megacystis-microcolon-intestinal hypoperistalsis syndrome
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