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Does maternal drug ingestion cause megacystis microcolon intestinal hypoperistalsis syndrome? II. Bromide trial.
[megacystis-microcolon-intestinal hypoperistalsis syndrome]
Megacystis
Microcolon
Intestinal
Hypoperistalsis
Syndrome
(
MMIHS
)
is
a
congenital
disease
,
and
the
etiology
of
the
disease
is
unclear
.
It
is
speculated
that
maternal
ingestion
of
some
drugs
during
pregnancy
and
degeneration
of
smooth
muscle
cells
in
the
fetus
may
be
an
etiologic
factor
.
In
this
study
we
aimed
to
investigate
the
effect
of
maternal
ingestion
of
bromide
on
the
fetal
bladder
and
colon
in
pregnant
rats
.
We
separated
animals
into
a
bromide
group
including
30
rats
and
a
control
group
with
14
rats
.
Nothing
was
given
to
the
control
group
during
pregnancy
.
Intraperitoneally
8
mg
/
kg
/
day
bromide
was
given
to
the
study
group
from
the
6
th
to
12
th
day
of
pregnancy
.
All
of
the
rats
were
sacrificed
on
the
20
th
day
of
pregnancy
.
Histopathological
examination
of
fetal
colons
and
bladders
was
performed
.
In
the
bromide
group
,
an
increase
in
the
colon
and
bladder
diameter
,
an
increase
in
muscle
atrophy
in
the
colon
and
bladder
wall
,
an
increase
in
vacuolar
degeneration
in
the
muscles
of
the
bladder
and
colon
wall
,
and
a
significant
decrease
in
ganglion
cell
numbers
in
the
myenteric
plexus
of
the
colon
and
bladder
were
determined
.
In
our
rat
model
,
we
found
histological
structural
changes
in
the
rats
'
colon
and
bladder
walls
as
a
result
of
using
bromide
on
the
6
-
12
th
days
of
pregnancy
similar
to
pathological
findings
found
in
some
of
MMIHS
patients
'
bowels
and
bladders
.
