Rare Diseases Symptoms Automatic Extraction

Lymphocytes and necrosis of the cutaneous microvasculature in malignant atrophic papulosis: a refined light microscope study.

[malignant atrophic papulosis]

Malignant atrophic papulosis is a disease characterized by multiple distinctive cutaneous and often lethal visceral infarctions. In some individuals, the diagnosis is not made until the skin manifestations are noted in a seriously ill patient with gastrointestinal and/or central nervous system disease. In other individuals, the disorder may pursue a benign course with only skin manifestations for many years. Using refined light microscopy to examine the skin lesions, the extensive nature of the necrotic microvascular alterations, a predominant lymphocytic infiltrate, and neural changes are documented. These findings suggest that the cutaneous lesions of malignant atrophic papulosis may result from a lymphocyte-mediated necrotizing vasculitis that affects the entire cutaneous microvasculature.

Diseases presenting "cutaneous lesions" symptom

  • child syndrome
  • cutaneous mastocytosis
  • cystinuria
  • dystrophic epidermolysis bullosa
  • gm1 gangliosidosis
  • harlequin ichthyosis
  • inclusion body myositis
  • lamellar ichthyosis
  • malignant atrophic papulosis
  • papillon-lefèvre syndrome
  • systemic capillary leak syndrome

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