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Lymphocytes and necrosis of the cutaneous microvasculature in malignant atrophic papulosis: a refined light microscope study.
[malignant atrophic papulosis]
Malignant
atrophic
papulosis
is
a
disease
characterized
by
multiple
distinctive
cutaneous
and
often
lethal
visceral
infarctions
.
In
some
individuals
,
the
diagnosis
is
not
made
until
the
skin
manifestations
are
noted
in
a
seriously
ill
patient
with
gastrointestinal
and
/
or
central
nervous
system
disease
.
In
other
individuals
,
the
disorder
may
pursue
a
benign
course
with
only
skin
manifestations
for
many
years
.
Using
refined
light
microscopy
to
examine
the
skin
lesions
,
the
extensive
nature
of
the
necrotic
microvascular
alterations
,
a
predominant
lymphocytic
infiltrate
,
and
neural
changes
are
documented
.
These
findings
suggest
that
the
cutaneous
lesions
of
malignant
atrophic
papulosis
may
result
from
a
lymphocyte-mediated
necrotizing
vasculitis
that
affects
the
entire
cutaneous
microvasculature
.