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Cutaneous manifestations of gastrointestinal disease: part II.
[malignant atrophic papulosis]
The
gastrointestinal
(
GI
)
and
cutaneous
organ
systems
are
closely
linked
.
In
part
I
of
this
continuing
medical
education
article
,
the
intricacies
of
this
relationship
were
explored
as
they
pertained
to
hereditary
polyposis
disorders
,
hamartomatous
disorders
,
and
paraneoplastic
disease
.
Part
II
focuses
on
the
cutaneous
system
's
links
to
inflammatory
bowel
disease
and
vascular
disorders
.
An
in
-depth
analysis
of
inflammatory
bowel
disease
skin
findings
is
provided
to
aid
dermatologists
in
recognizing
and
facilitating
early
consultation
and
intervention
by
gastroenterologists
.
Cutaneous
signs
of
inflammatory
bowel
disease
include
fissures
and
fistulae
,
erythema
nodosum
,
pyoderma
gangrenosum
,
pyostomatitis
vegetans
,
oral
aphthous
ulcers
,
cutaneous
polyarteritis
nodosa
,
necrotizing
vasculitis
,
and
epidermolysis
bullosa
acquisita
.
Additional
immune-mediated
conditions
,
such
as
diverticulitis
,
bowel
-associated
dermatosis-
arthritis
syndrome
,
Henoch-
Schönlein
purpura
,
dermatitis
herpetiformis
,
and
Degos
disease
,
in
which
the
skin
and
GI
system
are
mutually
involved
,
will
also
be
discussed
.
Genodermatoses
common
to
both
the
GI
tract
and
the
skin
include
Hermansky-
Pudlak
syndrome
,
pseudoxanthoma
elasticum
,
Ehlers-
Danlos
syndrome
,
hereditary
hemorrhagic
telangiectasia
,
and
blue
rubber
bleb
nevus
syndrome
.
Kaposi
sarcoma
is
a
neoplastic
disease
with
lesions
involving
both
the
skin
and
the
gastrointestinal
tract
.
Acrodermatitis
enteropathica
,
a
condition
of
zinc
deficiency
,
likewise
affects
both
the
GI
and
dermatologic
systems
.
These
conditions
are
reviewed
with
updates
on
the
genetic
basis
,
diagnostic
and
screening
modalities
,
and
therapeutic
options
.
Finally
,
GI
complications
associated
with
vascular
disorders
will
also
be
discussed
.
Diseases
Validation
Diseases presenting
"hereditary hemorrhagic telangiectasia"
symptom
hereditary cerebral hemorrhage with amyloidosis
kallmann syndrome
malignant atrophic papulosis
waldenström macroglobulinemia
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