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Role of inhaled amphotericin in allergic bronchopulmonary aspergillosis.
[allergic bronchopulmonary aspergillosis]
Allergic
bronchopulmonary
aspergillosis
(
ABPA
)
is
an
immunological
pulmonary
disorder
caused
by
immune
reactions
mounted
against
the
ubiquitous
fungus
Aspergillus
fumigatus
.
The
disease
clinically
manifests
with
poorly
controlled
asthma
,
hemoptysis
,
systemic
manifestations
like
fever
,
anorexia
and
weight
loss
,
fleeting
pulmonary
opacities
and
bronchiectasis
.
The
natural
course
of
the
disease
is
characterized
by
repeated
episodes
of
exacerbations
.
Almost
30
-
40
%
of
the
patients
require
prolonged
therapy
,
which
currently
consists
of
corticosteroids
and
anti-fungal
azoles
;
both
these
agents
have
significant
adverse
reactions
.
Amphotericin
B
administered
via
the
inhaled
route
can
achieve
a
high
concentration
in
the
small
airways
with
minimal
systemic
side-effects
.
Nebulized
amphotericin
B
has
been
used
in
the
management
of
invasive
pulmonary
aspergillosis
.
The
aim
of
this
review
is
to
study
the
utility
of
inhaled
amphotericin
in
ABPA
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated