Rare Diseases Symptoms Automatic Extraction
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Pediatric neurological complications associated with the A(H1N1)pdm09 influenza infection.
[locked-in syndrome]
Influenza-related
neurological
complications
(
INC
)
have
been
reported
during
seasonal
flu
in
children
.
To
investigate
the
types
,
outcomes
and
incidence
of
INC
occurring
during
the
2009
A
(
H
1
N
1
)
pandemic
,
a
retrospective
analyze
was
conducted
in
the
single
French
pediatric
hospital
of
Lyon
from
October
2009
to
February
2010
.
All
children
presenting
with
fever
,
influenza-like
illness
,
respiratory
distress
or
neurological
symptoms
were
tested
for
influenza
A
(
H
1
N
1
)
pdm
09
infection
from
respiratory
specimens
using
real
time
RT-PCR
.
INC
occurred
in
14
A
(
H
1
N
1
)
pdm
09
positive
children
(
7
.
7
%
of
A
(
H
1
N
1
)
pdm
09
positive
children
admitted
to
hospital
)
with
a
median
age
of
5
.
1
years
.
Admission
to
the
intensive
care
unit
(
ICU
)
was
required
for
nine
children
(
64
.
3
%
)
.
Half
of
the
children
with
INC
had
comorbidity
and
three
had
coinfection
,
both
characteristics
mainly
found
in
children
requiring
the
ICU
.
All
children
received
oral
oseltamivir
treatment
.
Febrile
seizures
were
observed
in
eight
children
,
half
of
them
having
a
chronic
comorbidity
(
2
epilepsy
,
1
nonketotic
hyperglycinemia
,
1
anoxic
encephalopathy
)
.
Other
INC
,
less
commonly
reported
,
included
2
cases
of
encephalitis
,
1
encephalopathy
,
1
basilar
artery
thrombosis
,
1
myasthenic
crisis
and
1
coma
.
Eleven
of
the
14
children
(
78
.
6
%
)
recovered
,
one
had
a
minor
disability
,
one
child
developed
a
locked-
in
syndrome
and
one
died
from
complications
of
an
acute
necrotizing
encephalopathy
.
INC
can
be
observed
even
in
children
with
no
underlying
disorder
.
It
may
lead
to
dramatic
issue
in
a
significant
number
of
cases
.
Diseases
Validation
Diseases presenting
"epilepsy"
symptom
22q11.2 deletion syndrome
adrenomyeloneuropathy
alexander disease
canavan disease
classical phenylketonuria
cohen syndrome
cowden syndrome
familial hypocalciuric hypercalcemia
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
homocystinuria without methylmalonic aciduria
kabuki syndrome
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neonatal adrenoleukodystrophy
pendred syndrome
phenylketonuria
proteus syndrome
pyruvate dehydrogenase deficiency
sneddon syndrome
wolf-hirschhorn syndrome
zellweger syndrome
This symptom has already been validated