Rare Diseases Symptoms Automatic Extraction
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Pediatric neurological complications associated with the A(H1N1)pdm09 influenza infection.
[locked-in syndrome]
Influenza-related
neurological
complications
(
INC
)
have
been
reported
during
seasonal
flu
in
children
.
To
investigate
the
types
,
outcomes
and
incidence
of
INC
occurring
during
the
2009
A
(
H
1
N
1
)
pandemic
,
a
retrospective
analyze
was
conducted
in
the
single
French
pediatric
hospital
of
Lyon
from
October
2009
to
February
2010
.
All
children
presenting
with
fever
,
influenza-like
illness
,
respiratory
distress
or
neurological
symptoms
were
tested
for
influenza
A
(
H
1
N
1
)
pdm
09
infection
from
respiratory
specimens
using
real
time
RT-PCR
.
INC
occurred
in
14
A
(
H
1
N
1
)
pdm
09
positive
children
(
7
.
7
%
of
A
(
H
1
N
1
)
pdm
09
positive
children
admitted
to
hospital
)
with
a
median
age
of
5
.
1
years
.
Admission
to
the
intensive
care
unit
(
ICU
)
was
required
for
nine
children
(
64
.
3
%
)
.
Half
of
the
children
with
INC
had
comorbidity
and
three
had
coinfection
,
both
characteristics
mainly
found
in
children
requiring
the
ICU
.
All
children
received
oral
oseltamivir
treatment
.
Febrile
seizures
were
observed
in
eight
children
,
half
of
them
having
a
chronic
comorbidity
(
2
epilepsy
,
1
nonketotic
hyperglycinemia
,
1
anoxic
encephalopathy
)
.
Other
INC
,
less
commonly
reported
,
included
2
cases
of
encephalitis
,
1
encephalopathy
,
1
basilar
artery
thrombosis
,
1
myasthenic
crisis
and
1
coma
.
Eleven
of
the
14
children
(
78
.
6
%
)
recovered
,
one
had
a
minor
disability
,
one
child
developed
a
locked-
in
syndrome
and
one
died
from
complications
of
an
acute
necrotizing
encephalopathy
.
INC
can
be
observed
even
in
children
with
no
underlying
disorder
.
It
may
lead
to
dramatic
issue
in
a
significant
number
of
cases
.
Diseases
Validation
Diseases presenting
"respiratory distress"
symptom
cohen syndrome
congenital diaphragmatic hernia
cutaneous mastocytosis
dentinogenesis imperfecta
erdheim-chester disease
familial hypocalciuric hypercalcemia
harlequin ichthyosis
heparin-induced thrombocytopenia
junctional epidermolysis bullosa
legionellosis
locked-in syndrome
neuralgic amyotrophy
scrub typhus
systemic capillary leak syndrome
typhoid
This symptom has already been validated