Rare Diseases Symptoms Automatic Extraction
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Liposarcoma miRNA signatures identified from genome-wide miRNA expression profiling.
[liposarcoma]
To
identify
the
miRNA
expression
profile
of
liposarcoma
(
LPS
)
that
could
facilitate
detection
of
LPS
,
and
provide
the
basis
for
further
investigation
of
molecular-targeted
therapeutic
drugs
.
A
real-time
quantitative
PCR
assay
was
performed
to
analyze
the
expression
of
1888
miRNAs
from
25
LPS
tumor
tissue
samples
,
16
samples
of
adipose
tissue
adjacent
to
the
tumors
and
18
normal
adipose
tissue
samples
from
patients
with
LPS
.
T
en
dysregulated
miRNAs
were
identified
that
effectively
distinguished
LPS
tissue
from
adipose
tissue
and
benign
lipoma
tissue
,
and
LPS
tumor
tissues
from
normal
adipose
tissues
in
LPS
patients
.
Furthermore
,
the
expression
profiles
of
miRNAs
could
also
classify
the
subtype
of
LPS
.
T
he
identified
miRNAs
appear
to
be
novel
biomarkers
for
the
detection
of
LPS
,
and
may
contribute
to
an
understanding
of
the
mechanisms
of
LPS
tumorigenesis
and
its
development
,
and
further
elucidate
the
characteristics
of
LPS
subtypes
.
