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Malignant phyllodes tumor of the breast with liposarcomatous differentiation and intraductal hyperplasia.
[liposarcoma]
Phyllodes
tumor
of
the
breast
is
a
biphasic
fibroepithelial
neoplasm
.
10
to
20
%
of
phyllodes
tumor
show
malignant
transformation
,
often
in
the
form
of
stroma
,
which
usually
shows
fibrosarcomatous
differentiation
and
rarely
heterologous
sarcomatous
elements
.
Liposarcomatous
differentiation
is
not
common
among
phyllodes
tumors
.
The
correct
diagnosis
of
heterologous
liposarcomatous
differentiation
in
a
malignant
PT
requires
identification
of
the
biphasic
component
of
the
tumor
.
We
reported
a
case
of
malignant
phyllodes
tumor
which
initially
transformed
into
liposarcoma
,
in
addition
to
a
very
rare
intraductal
hyperplasia
and
flat
epithelial
atypia
.
The
patient
was
a
75
-
year
-old
woman
,
with
a
lump
in
the
left
breast
without
axillary
lymphadenopathy
.
She
also
have
a
positive
family
history
of
breast
carcinoma
.
She
underwent
surgery
and
still
alive
and
disease
free
after
one
year
.
Diseases
Validation
Diseases presenting
"malignant transformation"
symptom
achondroplasia
adrenal incidentaloma
child syndrome
cholangiocarcinoma
cutaneous mastocytosis
epidermolysis bullosa simplex
esophageal adenocarcinoma
liposarcoma
oral submucous fibrosis
severe combined immunodeficiency
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