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A random Abstract
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Identification of a gene expression driven progression pathway in myxoid liposarcoma.
[liposarcoma]
to
investigate
the
events
involved
in
the
progression
of
myxoid
liposarcoma
(
MLS
)
.
Gene
expression
profiling
and
immunohistochemical
/
biochemical
analyses
were
applied
to
specimens
representative
of
the
opposite
ends
of
the
MLS
spectrum
:
pure
myxoid
(
ML
)
and
pure
round
cell
(
RC
)
liposarcomas
.
The
analyses
revealed
the
involvement
of
both
coding
and
non
coding
RNAs
(
SNORDs
located
in
DLK
1
-
DIO
3
region
)
and
support
a
model
of
stepwise
progression
mainly
driven
by
epigenetic
changes
involving
tumour
vascular
supply
and
tumoral
cellular
component
.
In
this
model
,
a
switch
in
the
vascular
landscape
from
a
normal
to
a
pro-angiogenic
signature
and
the
silencing
of
DLK
1
-
DIO
3
region
mark
the
progression
from
ML
to
RC
in
concert
with
the
acquisition
by
the
latter
of
the
over-expression
of
YYI
/
C-
MYC
/
HDAC
2
,
together
with
over-expression
of
genes
involved
in
cell
proliferation
and
stemness
:
MKNK
2
,
MSX
1
and
TRIM
71
.
Taken
together
,
these
findings
strongly
suggest
that
to
progress
from
ML
to
RC
liposarcoma
the
cells
have
to
overcome
the
epigenetic
silencing
restriction
point
in
order
to
reset
their
new
stem-like
differentiation
signature
.
Our
findings
provide
a
first
attempt
at
identifying
the
missing
links
between
ML
and
RC
liposarcomas
,
that
may
also
have
broader
applications
in
other
clinico-pathological
settings
characterised
by
a
spectrum
of
progression
.
Diseases
Validation
Diseases presenting
"first attempt"
symptom
liposarcoma
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