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Bone and Soft Tissue Pathology: SC02-3 ANGIOFIBROMA OF SOFT TISSUE.
[liposarcoma]
Angiofibroma
of
soft
tissue
arising
in
the
thigh
of
a
54
-
year
-old
female
will
be
demonstrated
.
Grossly
,
well
circumscribed
tumor
showed
grayish
white
color
with
focal
gelatinous
appearance
on
its
cut
surface
.
Histologically
,
the
tumor
is
composed
of
oval
to
short
spindle-shaped
cells
arranged
in
patternless
pattern
,
accompanied
by
slit-like
or
hemangiopericytomatous
vessels
,
fibro-collagenous
or
myxoid
stroma
.
Immunohistochemically
,
tumor
cells
are
negative
for
CD
34
,
myogenic
,
myoepithelial
or
epithelial
markers
.
INI
1
expression
is
preserved
.
Characteristic
AHRR
-
NCOA
2
fusion
transcript
was
detected
by
RT-PCR
.
This
tumor
is
characterized
by
two
components
:
uniformly
proliferating
bland
spindle
shaped
cells
in
fibro-collagenous
or
myxoid
stroma
,
and
prominent
vascular
network
composed
of
small
,
branching
hemangiopericytomatous
,
and
thin
walled
blood
vessels
.
In
this
slide
seminar
detailed
clinicopathological
features
of
angiofibroma
of
soft
tissue
will
be
demonstrated
.
Moreover
,
the
differential
diagnosis
of
this
peculiar
tumor
including
cellular
angiofibroma
,
solitary
fibrous
tumor
,
low
-grade
fibromyxoid
sarcoma
and
low
-grade
myxofibrosarcoma
or
myxoid
/
round
cell
liposarcoma
will
be
explained
.
Diseases
Validation
Diseases presenting
"blood vessels"
symptom
cadasil
coats disease
cushing syndrome
esophageal adenocarcinoma
hereditary cerebral hemorrhage with amyloidosis
hydrocephalus with stenosis of the aqueduct of sylvius
liposarcoma
lymphangioleiomyomatosis
malignant atrophic papulosis
oral submucous fibrosis
pyomyositis
sneddon syndrome
von hippel-lindau disease
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