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The biology of pulmonary aspergillus infections.
[allergic bronchopulmonary aspergillosis]
Pulmonary
aspergillus
infections
are
mainly
caused
by
Aspergillus
fumigatus
and
can
be
classified
based
on
clinical
syndromes
into
saphrophytic
infections
,
allergic
disease
and
invasive
disease
.
Invasive
pulmonary
aspergillosis
,
occurring
in
immunocompromised
patients
,
reflects
the
most
serious
disease
with
a
high
case-fatality
rate
.
Patients
with
cystic
fibrosis
and
severe
asthma
might
develop
allergic
bronchopulmonary
aspergillosis
,
while
saphrophytic
infections
are
observed
in
patients
with
lung
cavities
mainly
due
to
tuberculosis
.
Histopathologically
,
a
differentiation
can
be
made
into
angio-invasive
and
airway-invasive
disease
.
If
the
host
response
is
too
weak
or
too
strong
,
Aspergillus
species
are
able
to
cause
disease
characterized
either
by
damage
from
the
fungus
itself
or
through
an
exaggerated
inflammatory
response
of
the
host
,
in
both
situations
leading
to
overt
disease
associated
with
specific
clinical
signs
and
symptoms
.
The
unraveling
of
the
specific
host
-
Aspergillus
interaction
has
not
been
performed
to
a
great
extent
and
needs
attention
to
improve
the
management
of
those
clinical
syndromes
.
Diseases
Validation
Diseases presenting
"can be classified based on clinical syndromes into saphrophytic infections"
symptom
allergic bronchopulmonary aspergillosis
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