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Successful treatment of Candida albicans septicemia in a preterm infant with severe congenital ichthyosis (Harlequin baby).
[lamellar ichthyosis]
Candida
infections
are
a
major
cause
of
fungal
septicemia
in
neonates
and
are
associated
with
marked
morbidity
and
mortality
.
Despite
the
spectrum
of
antifungal
drugs
being
dramatically
extended
during
the
last
decade
,
invasive
fungal
infections
remain
a
serious
challenge
for
neonatologists
.
Amphotericin
B
and
its
lipid
formulations
are
the
drugs
of
choice
for
the
treatment
of
systemic
candidiasis
in
neonates
.
The
combination
of
antifungal
drugs
with
different
sites
of
action
,
like
caspofungin
and
amphotericin
B
,
may
improve
antifungal
efficacy
.
Severe
congenital
ichthyosis
often
leads
to
death
within
the
neonatal
period
.
Main
causes
of
death
are
dehydration
,
electrolyte
disturbances
,
and
respiratory
or
systemic
infections
.
We
report
the
case
of
a
preterm
infant
with
severe
congenital
ichthyosis
and
sepsis
caused
by
Candida
albicans
.
The
infection
did
not
improve
despite
proper
liposomal
amphotericin
B
treatment
.
After
addition
of
caspofungin
,
the
baby
recovered
.
To
our
best
knowledge
,
a
case
of
a
preterm
infant
suffering
from
severe
congenital
ichthyosis
and
Candida
albicans
sepsis
,
who
survived
,
has
not
been
previously
described
.
Diseases
Validation
Diseases presenting
"neonatal period"
symptom
alexander disease
alpha-thalassemia
benign recurrent intrahepatic cholestasis
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cutaneous mastocytosis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
harlequin ichthyosis
hirschsprung disease
homocystinuria without methylmalonic aciduria
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neonatal adrenoleukodystrophy
neuralgic amyotrophy
pyruvate dehydrogenase deficiency
zellweger syndrome
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