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Increased melanocytic nevi in patients with inherited ichthyoses: report of a previously undescribed association.
[lamellar ichthyosis]
Ichthyosis
is
a
heterogeneous
cornification
disorder
.
Melanocytic
lesions
have
not
been
previously
described
in
association
with
ichthyosis
.
Their
clinical
importance
lies
in
the
fact
that
they
may
simulate
melanoma
clinically
and
dermoscopically
,
as
seen
in
epidermolysis
bullosa
.
The
objective
of
this
study
was
to
evaluate
the
clinical
,
dermoscopic
,
and
histopathologic
features
of
nevi
and
lentigines
in
16
patients
with
autosomal
recessive
congenital
ichthyosis
-
lamellar
ichthyosis
and
nonbullous
ichthyosiform
congenital
erythroderma
.
Patients
underwent
general
clinical
examination
dermoscopy
.
The
more
suspicious
lesions
were
excised
and
to
histopathologic
examination
.
Most
patients
(
n
=
13
)
reported
no
personal
or
familial
history
of
melanoma
or
atypical
nevi
.
All
of
the
patients
had
at
least
five
atypical
melanocytic
lesions
.
Ten
of
the
16
patients
had
at
least
one
atypical
nevus
or
lentigo
.
This
study
suggests
that
increased
atypical
melanocytic
nevi
may
be
a
feature
of
long
-standing
congenital
ichthyoses
.
Whether
this
finding
is
disease-related
or
a
coincidental
observation
is
difficult
to
ascertain
.
As
an
unequivocal
discrimination
from
malignant
melanoma
in
vivo
is
not
always
possible
,
regular
clinical
follow-up
of
patients
with
ichthyosis
and
increased
or
unusual
nevi
is
recommended
.
Diseases
Validation
Diseases presenting
"ichthyosis"
symptom
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
harlequin ichthyosis
hirschsprung disease
junctional epidermolysis bullosa
kallmann syndrome
lamellar ichthyosis
This symptom has already been validated