An overview of interleukin-1 receptor antagonist, anakinra, in the treatment of cutaneous diseases.

[lamellar ichthyosis]

Interleukin (IL )-1 is a pivotal proinflammatory cytokine consisting of two molecular species , IL -1 α and IL -1 β . Anakinra (Kineret ), a recombinant human IL -1 receptor antagonist , is regarded as a biological agent which blocks the inflammatory effects of IL -1 . The aim of this review was to search the literatures and summarizes in vivo , in vitro and human studies on anakinra uses in dermatological disorders . The results show that anakinra is currently used clinically for the treatment of a variety of skin conditions such as psoriasis , atopic dermatitis , photoagaing , melanoma , Schnitzler syndrome , pyoderma gangraenosum , PAPA syndrome , hidradenitis suppurativa , lamellar ichthyosis , Sweet 's syndrome , panniculitis , Muckle-Wells syndrome , familial Mediterranean fever , SAPHO syndrome and other disorders . Notably , anakinra is expensive to produce and administer . Injection is the route of therapy and allergic reaction is most possible .

Diseases
Validation

Diseases presenting "fever" symptom

22q11.2 deletion syndrome

acute rheumatic fever

alexander disease

allergic bronchopulmonary aspergillosis

canavan disease

carcinoma of the gallbladder

child syndrome

congenital toxoplasmosis

cushing syndrome

cystinuria

dracunculiasis

erdheim-chester disease

esophageal adenocarcinoma

esophageal carcinoma

familial mediterranean fever

focal myositis

hodgkin lymphoma, classical

lamellar ichthyosis

legionellosis

locked-in syndrome

malignant atrophic papulosis

neonatal adrenoleukodystrophy

neuralgic amyotrophy

oculocutaneous albinism

papillon-lefèvre syndrome

pyomyositis

pyruvate dehydrogenase deficiency

scrub typhus

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

typhoid

waldenström macroglobulinemia

wolf-hirschhorn syndrome

This symptom has already been validated