Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Concise Synthesis of the Unnatural Sphingosine and Psychosine Enantiomer.
[krabbe disease]
The
accumulation
of
psychosine
(
galactosyl
sphingosine
)
has
been
associated
with
the
pathogenesis
of
Krabbe
disease
,
however
,
the
exact
mechanism
of
its
cytotoxicity
remains
unclear
.
Herein
,
we
describe
the
synthesis
of
the
unnatural
enantiomer
of
erythrosphingosine
,
psychosine
,
and
related
derivatives
thereof
that
would
allow
for
the
mechanistic
elucidation
of
the
toxicity
of
psychosine
.