Genetic screening for Krabbe disease: learning from the past and looking to the future.

[krabbe disease]

In Israel , Krabbe disease is frequent in two Moslem Arab villages in the Jerusalem area . In this paper we present our experience of almost four decades with diagnosis of Krabbe disease , carrier screening and prenatal diagnosis . The screening program is well accepted by the community , and there is a clear trend towards premarital testing . The screening program and prenatal diagnosis have led to a decrease in the incidence of Krabbe disease from 1 .6 per 1 ,000 live births to 0 .82 per 1 ,000 .