Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
The Kindlin protein family: new members to the club of focal adhesion proteins.
[kindler syndrome]
Kindlins
are
a
group
of
proteins
that
have
recently
attracted
attention
for
their
ability
to
bind
and
activate
integrins
.
Moreover
,
they
have
also
been
linked
to
inherited
and
acquired
human
diseases
including
Kindler
syndrome
,
leukocyte
adhesion
deficiency
,
and
cancer
.
Although
most
studies
have
focused
on
kindlins
as
key
regulatory
components
of
cell-extracellular
matrix
junctions
such
as
focal
adhesions
,
preliminary
data
suggest
the
involvement
of
additional
cellular
compartments
in
mediating
their
functions
,
particularly
at
cell-cell
contacts
and
the
nucleus
.
Investigating
the
many
roles
of
kindlins
is
likely
to
expand
and
sharpen
our
view
on
the
versatility
of
integrin-mediated
cell
adhesion
,
the
nuclear
function
of
focal
adhesion
proteins
,
and
the
crosstalk
between
cell-cell
and
cell-matrix
adhesions
in
health
and
disease
.
Diseases
Validation
Diseases presenting
"preliminary data suggest the involvement of additional cellular compartments in mediating their functions"
symptom
kindler syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom