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The Kindlin protein family: new members to the club of focal adhesion proteins.
[kindler syndrome]
Kindlins
are
a
group
of
proteins
that
have
recently
attracted
attention
for
their
ability
to
bind
and
activate
integrins
.
Moreover
,
they
have
also
been
linked
to
inherited
and
acquired
human
diseases
including
Kindler
syndrome
,
leukocyte
adhesion
deficiency
,
and
cancer
.
Although
most
studies
have
focused
on
kindlins
as
key
regulatory
components
of
cell-extracellular
matrix
junctions
such
as
focal
adhesions
,
preliminary
data
suggest
the
involvement
of
additional
cellular
compartments
in
mediating
their
functions
,
particularly
at
cell-cell
contacts
and
the
nucleus
.
Investigating
the
many
roles
of
kindlins
is
likely
to
expand
and
sharpen
our
view
on
the
versatility
of
integrin-mediated
cell
adhesion
,
the
nuclear
function
of
focal
adhesion
proteins
,
and
the
crosstalk
between
cell-cell
and
cell-matrix
adhesions
in
health
and
disease
.
